Best Energy Supplements for Chronic Fatigue: Top 7 Expert Reviews

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Medically reviewed by Drew Sutton

Performance Lab Caffeine

Performance Lab Caffeine+

  • It uses precision dosing.
  • It is vegan approved.
  • It is gluten-free, without artificial colors.

New Chapter Fermented Coenzyme B Complex

New Chapter Fermented Coenzyme B Complex

  • 8 fermented B vitamins in one capsule
  • Manufactured with certified organic vegetables & herbs
  • Absorbs easily because it’s fermented

GreeNatr Panax Ginseng + Ginkgo Biloba Tablets

GreeNatr Panax Ginseng + Ginkgo Biloba Tablets

  • Strong blend of Ginseng and Ginkgo Biloba
  • All-natural and GMO-free product
  • Suitable for vegans/vegetarians

Many people worldwide are at peak energy and stress levels. 73% of respondents to a US March 2022 stress survey[1] disclosed feeling overwhelmed by the extent of crises worldwide. According to the NIMH[2], chronic fatigue can negatively impact every aspect of your health and contribute to a wide range of problems like the risk of high blood pressure[3], stroke, and heart attack.

This article explores the best energy supplements that can help eliminate that fatigue[4] and support energy levels in a systemic way.

Energizing Supplements

Energy is something we all strive to have or maintain. And well-established research has found many energizing supplements and herbs can naturally boost energy on a cellular level. Usually, it is always better to acquire vitamins from our consumed meals. But with the inability to meet the daily requirement through food alone, you may reach for these supplements[5] to make the difference.  

These supplements are crucial in improving feelings of chronic fatigue and resetting the body. They employ special plant extracts and other ingredients that offer a rush of energy when feeling drained or exhausted without the toxic effects of numerous stimulants.

The Line Up At A Glance

Performance Lab Caffeine

Performance Lab Caffeine+

  • It uses precision dosing.
  • It is vegan approved.
  • It is gluten-free, without artificial colors.

New Chapter Fermented Coenzyme B Complex

New Chapter Fermented Coenzyme B Complex

  • 8 fermented B vitamins in one capsule
  • Manufactured with certified organic vegetables & herbs
  • Absorbs easily because it’s fermented

GreeNatr Panax Ginseng + Ginkgo Biloba Tablets

GreeNatr Panax Ginseng + Ginkgo Biloba Tablets

  • Strong blend of Ginseng and Ginkgo Biloba
  • All-natural and GMO-free product
  • Suitable for vegans/vegetarians

Qunol Ultra CoQ10

Qunol Ultra CoQ10

  • Restores normal CoQ10 levels
  • Provides antioxidant capabilities
  • It helps protect against heart issues.

Thorne Memoractiv

Thorne Memoractiv

  • It does not contain dairy, gluten, or artificial flavors.
  • Protects against vision damage
  • It intensifies the mind’s ability to focus.

Double Wood Rhodiola Rosea

Double Wood Rhodiola Rosea

  • Organic and natural product
  • It helps the body adapt to pressure and decreases fatigue.
  • Natural antidepressant

Nurish by Nature Made Melatonin 3 mg + L-theanine

Nurish by Nature Made Melatonin 3 mg + L-theanine

  • Free from preservatives, or artificial flavors
  • It is gluten-free.
  • Helps relax the mind and support sleep

Top 7 Best Energy Supplements for Chronic Fatigue 2022

Performance Lab Caffeine+

Performance Lab Caffeine

PL Caffeine + is one of the best caffeine supplements if scrutinizing for improved performance all day. Its low-dose caffeine formula is conceived to help with prolonged focus without any downsides. 

  • Caffeine + utilizes only the finest ingredients backed by science[6]
  • It uses precision dosing.
  • It is vegan approved, non-GMO and non-irradiated.
  • It is gluten-free, without synthetic additives, artificial colors, or preservatives.
  • It can be taken with more traditional caffeine sources.
  • Caffeine dosage is low, different from traditional caffeine pills.
  • Some of the website’s terminologies often feel quite confusing.
  • It is not cheap.
  • It is only available for purchase directly at the website.

Caffeine + has a tolerable dose of caffeine that allows dosage[7] adjustment and its brain-protecting amino acids and B-vitamins. Most people play around with how Caffeine + works for them and enjoy the flexibility of making up their dosage. This is with the awareness of the daily healthy maximum caffeine dosage per day of around 400mg.

It is a healthier, cleaner choice when you require an energy boost or a cognitive aid. It is not reliant on caffeine and facilitates brain benefits, which are more than just alertness and stimulation.

Their intelligent formula is hit with complementary ingredients such as L-Tyrosine and L-Theanine to counteract the negative effects of caffeine consumption. At the same time, they offer a more regular and sustained discharge of energy[8] throughout the day.

There are no explicit benefits for a certain demographic. As such, anyone wanting a cognitive boost (or a physical one) or to lessen their alternative caffeine intake can take this supplement. Those who don’t habitually use caffeine would see outstanding results from taking Caffeine +.

New Chapter Fermented Coenzyme B Complex

New Chapter Fermented Coenzyme B Complex

This Coenzyme B complex is an absolute vitamin B supplement with a distinctive edge: fermented with probiotics and whole foods. One capsule per day sustains the nervous system and power household.

  • Absorbs easily because it’s fermented
  • 8 fermented B vitamins in one capsule
  • Manufactured with certified organic vegetables & herbs
  • Non-GMO, gluten-free, and 100% Vegetarian
  • 100% daily value of Biotin for healthy hair and nails
  • No artificial flavors, colors, or Synthetic Fillers
  • Not suitable for those with soy allergies
  • A 60- tablet bottle is not cheap.

This product contains 8 B vitamins, including B12, fermented with whole foods (unrefined, unprocessed food), and augmented with an organic spice blend (including organic Maca & Grape Seed). It assists the body in processing food into energy and reinforces the nervous system’s regular activity. 

B vitamins, jointly with mitochondria, the cells’ miniature power plants, help to supply energy for the day-to-day active work or sports training schedules. 

During fermentation, the probiotics trigger the organic vegetables and herbs and convert essential nutrients into a whole food, fermented form. And the result is an easy-to-digest supplement that can be utilized even on an empty stomach. 

GreeNatr Panax Ginseng + Ginkgo Biloba Tablets

GreeNatr Panax Ginseng + Ginkgo Biloba Tablets

Very effective because both Ginseng and Ginkgo Biloba hold active ingredients that elevate overall health. These two herbal blends can enhance brain functions, mainly your memory.

  • A strong combination of Ginseng and Ginkgo Biloba
  • All-natural and GMO-free product
  • Suitable for vegans/vegetarians
  • Sixty-day return policy
  • May interfere with diabetes medication
  • Can trigger allergies, nausea, and dizziness

A mixture of Panax Ginseng and Ginkgo Biloba used in traditional Chinese, and Indian health, administer physiological symptoms linked with lack of dynamism and brain function. They perform in perfect synergy to enhance short- and long-term memory through a mechanism that builds up levels of memory-supporting chemicals in the brain[9]

Korean Ginseng is rich in antioxidants, which help subside inflammation and enhances the body’s immunity. It is popular for enhancing mental function and restricting stress hormones. Ginseng[10] also energizes the body by dropping oxidative damage caused by free radicals.

Ginkgo Biloba is rich in antioxidants also, and a natural anti-inflammatory agent. This helps reduce circulatory and respiratory system diseases. The extract behaves as a vasodilatory agent, improving the body’s circulation and vision. It is equally linked with improving mental vigilance and attention, slowing neurodegenerative disorders like Alzheimer’s and dementia. 

Together, Panax Ginseng and Ginkgo Biloba reduce stress and anxiety, improve vision, and experience frequent bursts of mood swings will be consumed.

Qunol Ultra CoQ10

Qunol Ultra CoQ10

Ultra CoQ10 is a reasonable option to boost energy and support heart health. Low levels of this coenzyme have been linked with older adults, those with cardiovascular disease, and COPD. Thus, supplementation is advantageous

  • Restores normal CoQ10 levels
  • Dissolves in both water and fat
  • It is 100% natural.
  • Assists in managing blood pressure
  • Provides antioxidant capabilities
  • It helps protect against heart issues.
  • It may be a problem for people having trouble swallowing a pill.
  • Each bottle only comes with 30 days’ worth of pills.

Including diminishing the side effects of statin medications, Ultra CoQ10 may aid treat congestive heart failure and contain migraines. It also modestly lessens cholesterol levels. Ultra CoQ10 works as an electron transporter. This function is crucial for energy generation in the body. It offers two ingredients: 

Vitamin E – 150 IU 500% RDA:

Vitamin E[11], a powerful antioxidant, boosts immune function, promotes blood flow, and prevents blood clots. 

Coenzyme Q10 – 100mg:

The CoQ10 content of this supplement is known to be responsible for the primary benefits of Qunol. In a recent review, coenzyme Q10[12] enhanced fatigue in more than 60% of the studies[13]. These results were revealed in healthy people and those with chronic medical states. The benefit[14] was also revealed when the time to exhaustion during treadmill exercise improved[15] in those that consumed 200mg daily for 8 weeks.

Thorne Memoractiv

Thorne Memoractiv

This is a viable form of supplement. The ingredients help reduce cortisol levels, combat the effects of stress, and help the eyes filter light from blue screens.

  • It does not contain dairy, gluten, artificial flavors, or colors.
  • It supports a healthy memory.
  • It intensifies the mind’s ability to focus.
  • Protects against vision damage
  • Reducing levels of stress
  • 2 capsules per serving
  • It contains an ingredient derived from soy so that it can trigger soy allergies.
  • It is expensive.

Memoractiv is a distinctive blend of nootropic ingredients – substances that promote creativity and stimulation – which also can support brain health.

It contains six botanical extracts and nutrients that are well studied for providing cognitive benefits, including support for concentration, productivity, creativity, motivation, mental focus, and reaction time.

The basic nutrients cover the multivitamin bases without unnecessary extra herbs or enzymes, and it is free of unsafe levels of impurities and substances prohibited for athletes.

It includes the functional form of folate, which helps the body soak in and employ this nutrient. It also comprises vitamin K2, which is challenging for many people to obtain through diet (primarily in fermented dairy).

Although it retains more B-vitamins than required, our bodies can easily eliminate excess B vitamins. Therefore, these elements are not dangerous in extreme doses.

Additionally, Memoractiv includes four notable ingredients: 

  • Ginkgo Phytosome (Virtiva)- provides superior efficacy compared to the same standardized Ginkgo extract
  • Lutemax 2020 – helps the eyes filter the light from blue screens.
  • Ashwagandha – improves information processing and overall cognitive function.
  • Pterostilbene/Caffeine provides a sustained release of the caffeine at a lower dose.

Double Wood Rhodiola Rosea

Double Wood Rhodiola Rosea

Rhodiola Rosea regulates how we react to stress due to its distinct adaptogen properties. This supplement is excellent for vegans who work long hours but still desire to have ample energy for work-outs or friends hangout at the close of the day.

  • Vegan, Gluten Free and Non-GMO
  • It contains 3% of the active ingredient Salidrosides.
  • Organic and Natural Product
  • It helps the body adapt to pressure and decreases fatigue.
  • Natural antidepressant
  • Vegan-friendly capsules
  • Improves cognition, mood, and mental energy levels
  • It might be too intense.
  • Can cause bloating
  • May increase blood sugar
  • Can trigger allergies
  • You may experience nausea

Rhodiola Rosea is popularly known as Arctic root or Golden root, and it retains over 140 ingredients, of which salidroside is the most powerful. Salidroside has been shown to improve cognition, among many other benefits, such as anti-cancer properties[16].

Rhodiola acts as an adaptogen[17]. It boosts stress tolerance, elevates your mental health, enhances your brain function, and slashes down your cortisol levels. As well it aids in burning body fat when matched with proper exercise.

Taken as a supplement supports neuroprotection and stress tolerance and promotes energy levels. The high concentration enables people to maximize physical and mental energy levels for extended periods. Since it’s also in capsule form, one can take it anywhere, at any time.

Nurish by Nature Made Melatonin 3 mg + L-theanine

Nurish by Nature Made Melatonin 3 mg + L-theanine

Sleepers comfortable taking a softgel will likely find Melatonin a worthwhile choice. This product harbors a blend of melatonin and L-theanine that helps reliably relax and fall asleep.

  • It is free from preservatives, synthetic dies, or artificial flavors.
  • It is gluten-free.
  • Helps relax the mind and support sleep
  • Comes in softgels per pack

Melatonin is a hormone bred in the pineal gland in your brain, which helps to regulate sleep and wake cycles. L-theanine is a naturally emerging amino acid in green tea that supports your mind at ease.  

With a combination of L-theanine and Melatonin, this supplement becomes a naturally acting sleep aid that helps support restful sleep. It also contains 200 mg of the amino acid L-theanine, naturally found in black tea, and may help improve focus and sleep quality.  

Each softgel has 3 milligrams of melatonin, which is within the recommend

What Is Chronic Fatigue?

Chronic fatigue is classified as a neurological[18] disorder by WHO, which means muscle pain and brain and spinal cord inflammation.  The fatigue aggravates physical or mental activity but doesn’t get better with rest. It is a severe, long-term illness that influences many body systems[19].

Chronic Fatigue leads to a loss of productivity[20] and irritability that causes daily tasks to be difficult to conclude. Sometimes you may be unable to stand out of bed. 

How Does Energy Boosting Supplement Work?

Energy building in the body is a complex process. The metabolism is the chemical process that transforms proteins, carbohydrates, and fats from your meals into the energy[21] that your cells require to operate.

Energy-boosting supplements only provide your body with the tools it needs to function and feel its best. A few well-chosen supplements[22] can support to help you maintain all-day energy. Not all products[23] will function the same for every

Health Benefits & Side Effects Of Supplements For Energy

Health Benefits

Some studies also showed that energy supplements improve cognition and mood in sleep-deprived people who have them. They improve aerobic endurance, aerobic performance, and upper muscle endurance. Other benefits are:

  • Improved brain function
  • Improved mood
  • More concentration
  • Reduced mental fatigue

Side Effects

While taking energy supplements may appear harmless, there are some outcomes that you may observe if you incorporate them into your day—particularly if you are taking them regularly and in large quantities.

  • You may feel jittery
  • Men may experience fertility challenges
  • You may have trouble sleeping
  • You may experience improved endurance performance

Frequently Asked Questions

Are energy supplements safe?

In several studies, energy supplements have been discovered to boost physical endurance, but there’s less proof of any impact on muscle strength.

Can too many supplements be harmful?

Consuming a dose in excess is conceivable, which can lead to negative side effects. Overdosing on specific vitamins can lead to grave complications.

Can Supplements Improve Your Energy?

Some may impact, but others may require more examination to endorse the energy-boosting claims.

Do energy supplements affect the brain?

Simply consuming energy supplements won’t cause brain damage.

How do I know What supplements I need?

Not everyone requires a supplement – many people get the nutrients they need from a healthy, balanced diet. So, the first step is to understand if you need to obtain one.

What are the risks of taking dietary supplements?

Consuming more than you need may increase your risk of side effects.

What is the best supplement for chronic fatigue?

When it comes to chronic fatigue, no one supplement works for everyone. If you follow the guidelines above, it is likely to locate a product with the right energy boost your body requires.

Should I discuss with my doctor about taking these supplements?

Yes, always go to a doctor before starting a new vitamin regimen. In the course of examination, they may define the cause of chronic fatigue symptoms. Schedule an appointment with a physician to learn about fatigue and helpful vitamin supplements.


+ 23 sources

Tnhealth has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  1. “Stress in America.” Apa.org, 2022, www.apa.org/news/press/releases/stress/2022/march-2022-survival-mode.
  2. “NIMH» I’m so Stressed Out! Fact Sheet.” Www.nimh.nih.gov, www.nimh.nih.gov/health/publications/so-stressed-out-fact-sheet.
  3. “What Is High Blood Pressure? Symptoms, Causes, Diagnosis, Treatment, and Prevention | Everyday Health.” EverydayHealth.com, www.everydayhealth.com/high-blood-pressure/guide/.
  4. “Chronic Fatigue Syndrome.” Medlineplus.gov, National Library of Medicine, 2019, medlineplus.gov/chronicfatiguesyndrome.html.
  5. “Chronic Fatigue Syndrome.” Medlineplus.gov, National Library of Medicine, 2019, medlineplus.gov/chronicfatiguesyndrome.html.
  6. “Performance Lab Caffeine+ Review – Nootropics Expert.” Nootropicsexpert.com, nootropicsexpert.com/performance-lab-stim-review/.
  7. “Performance Lab Caffeine plus (Formerly Stim) Review: A Crash-Free Caffeine Pill.” Supplement Reviews UK, 9 Jan. 2022, www.supplementreviewsuk.com/energy/performance-lab-stim-review-the-cleaner-crash-free-caffeine-pill/.
  8. Gostincar, Greg. “Performance Lab Caffeine plus Review: Can It Do All It Promises?” Your Inception, 4 Jan. 2022, www.yourinception.com/performance-lab-caffeine-plus-review/. Accessed 14 Oct. 2022.
  9. LaSala, Gregory S., et al. “Effect of Single-Dose Ginkgo Biloba and Panax Ginseng on Driving Performance.” Clinical Toxicology (Philadelphia, Pa.), vol. 53, no. 2, 1 Feb. 2015, pp. 108–112, pubmed.ncbi.nlm.nih.gov/25597699/, 10.3109/15563650.2014.999159. Accessed 14 Oct. 2022.
  10. “GreeNatr Ginseng and Ginkgo Biloba Review.” Nootropics Resources, nootropicsresources.com/greenatr-ginseng-ginkgo-biloba-review/. Accessed 14 Oct. 2022.
  11. Böhm, Volker. “Vitamin E.” Antioxidants, vol. 7, no. 3, 20 Mar. 2018, p. 44, www.ncbi.nlm.nih.gov/pmc/articles/PMC5874530/, 10.3390/antiox7030044.
  12. Mehrabani, Sanaz, et al. “Effect of Coenzyme Q10 Supplementation on Fatigue: A Systematic Review of Interventional Studies.” Complementary Therapies in Medicine, vol. 43, Apr. 2019, pp. 181–187, 10.1016/j.ctim.2019.01.022.
  13. Mehrabani, Sanaz, et al. “Effect of Coenzyme Q10 Supplementation on Fatigue: A Systematic Review of Interventional Studies.” Complementary Therapies in Medicine, vol. 43, Apr. 2019, pp. 181–187, 10.1016/j.ctim.2019.01.022.
  14. Ho, Meghan J, et al. “Blood Pressure Lowering Efficacy of Coenzyme Q10 for Primary Hypertension.” Cochrane Database of Systematic Reviews, 7 Oct. 2009, 10.1002/14651858.cd007435.pub2. Accessed 8 Dec. 2020.
  15. Cooke, Matthew, et al. “Effects of Acute and 14-Day Coenzyme Q10 Supplementation on Exercise Performance in Both Trained and Untrained Individuals.” Journal of the International Society of Sports Nutrition, vol. 5, no. 1, 2008, p. 8, 10.1186/1550-2783-5-8.
  16. Zhong, Zhifeng, et al. “Pharmacological Activities, Mechanisms of Action, and Safety of Salidroside in the Central Nervous System.” Drug Design, Development and Therapy, vol. 12, 24 May 2018, pp. 1479–1489, www.ncbi.nlm.nih.gov/pmc/articles/PMC5973445/, 10.2147/DDDT.S160776. Accessed 14 Oct. 2022.
  17. “Double Wood Rhodiola Rosea Review.” Nootropics Resources, nootropicsresources.com/double-wood-rhodiola-rosea-review/. Accessed 14 Oct. 2022.
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Written by:

Petra Oglesbee, BA

Medically reviewed by:

Petra Oglesbee is writer, researcher and content creator with over 5 years of experience. Driven by science-backed results, she takes pride in providing the most comprehensive reviews and insights into medical and wellness products and treatments. With a degree in Speech in Hearing Sciences, Petra aims to help all readers become their own health advocates. She helps people use knowledge as a tool in navigating health concerns and living their best lives.

Medically reviewed by: